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Updated: Jun 15, 2025
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Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
Published on: April 19, 2013
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Transcriptomic analysis reveals cross-talk genes between type 2 diabetes and recurrent benign paroxysmal positional
Jing Hui1, Dingjing Zi2, LePing Liang2
1Department of Neurology, The Second Afliated Hospital of Xi'an Medical College, China.
Heliyon
|August 22, 2024
Summary
Type 2 diabetes mellitus (T2DM) recurrence of benign paroxysmal positional vertigo (BPPV) is linked to shared genes. Four immune-related hub genes were identified as biomarkers for predicting BPPV recurrence in T2DM patients.
Area of Science:
- Genomics
- Immunology
- Endocrinology
Background:
- Benign paroxysmal positional vertigo (BPPV) frequently recurs.
- Type 2 diabetes mellitus (T2DM) is a known risk factor for BPPV recurrence.
- The genomic links between T2DM and BPPV recurrence are not well understood.
Purpose of the Study:
- To identify shared genes between BPPV recurrence and T2DM.
- To investigate the role of immune-mediated pathways in the comorbidity.
- To discover potential biomarkers for predicting BPPV recurrence in T2DM patients.
Main Methods:
- Differential gene expression and co-expression network analyses were performed.
- Hub genes were identified using protein-protein interaction networks and MCC algorithm.
- Immune infiltration and gene-immune cell correlations were analyzed.
- Hub gene expression was validated in patient blood samples via qPCR.
Main Results:
- Thirteen shared genes between BPPV recurrence and T2DM were identified.
- Four hub genes were selected and demonstrated predictive efficacy for both conditions.
- These hub genes showed significant correlation with immune cell infiltration.
- Upregulation of hub genes was confirmed in T2DM patients with recurrent BPPV.
Conclusions:
- Shared genomic characteristics exist between BPPV recurrence and T2DM.
- Immune-mediated inflammatory regulation appears to be a common pathway.
- Four immune-related hub genes serve as potential biomarkers and therapeutic targets.
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