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Updated: Jun 15, 2025
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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
Published on: August 4, 2018
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Amidine containing compounds: Antimicrobial activity and its potential in combating antimicrobial resistance
Asmaa Zainal Abidin1, Mohd Nor Faiz Norrrahim2, Nik Noorul Shakira Mohamed Shakrin3
1Department of Chemistry and Biology, Centre for Defence Foundation Studies, Universiti Pertahanan Nasional Malaysia, Kem Perdana Sungai Besi, 57000 Kuala Lumpur, Malaysia.
Heliyon
|August 22, 2024
Summary
Antimicrobial resistance (AMR) is a global threat. Amidine compounds show promise for developing new antimicrobial drugs by targeting diverse pathogens and enhancing existing treatments.
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Microbiology
Background:
- Antimicrobial resistance (AMR) poses a significant and escalating threat to global public health.
- Innovative strategies are urgently required to combat the growing crisis of drug-resistant infections.
- Amidine-containing compounds have garnered attention as potential therapeutic agents against resistant microbes.
Purpose of the Study:
- To review recent advancements (past decade) in antimicrobial amidine-containing compounds.
- To highlight the structural diversity and pharmacological relevance of amidine moieties in antimicrobial activity.
- To explore the potential of these compounds in combating antimicrobial resistance.
Main Methods:
- Comprehensive literature review focusing on studies from the last ten years.
- Analysis of chemical structures of amidine-containing compounds in relation to their antimicrobial activities.
- Consolidation of current knowledge on antimicrobial mechanisms of amidine derivatives.
Main Results:
- Amidine incorporation or modification enhances the pharmacological properties of antimicrobial agents.
- Amidine-containing compounds exhibit broad-spectrum antimicrobial activities, including antibacterial, antifungal, and antiparasitic effects.
- Structural variations of amidine compounds correlate with diverse antimicrobial efficacies.
Conclusions:
- Amidine-containing compounds represent a promising class of agents for developing novel therapeutics against resistant microorganisms.
- Further research into the chemical structure-activity relationships and mechanisms of action is warranted.
- These compounds offer a viable strategy to address the global challenge of antimicrobial resistance.
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