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Related Experiment Video

Updated: Jun 15, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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Eudesmane-type sesquiterpenoids: Structural diversity and biological activity.

Guang-Xu Wu1,2, Hao-Yu Zhao1,2, Cheng Peng1

  • 1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Heliyon
|August 22, 2024
PubMed
Summary

This review details 391 eudesmane-type sesquiterpenoids discovered between 2016-2022. These natural compounds exhibit diverse biological activities, highlighting their medicinal potential.

Keywords:
Biological activityDistributionEudesmane-typePhytochemistrySesquiterpenoids

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Phytochemistry

Background:

  • Sesquiterpenoids, particularly eudesmane-type compounds, are abundant in plants.
  • Eudesmane sesquiterpenoids possess bicyclic structures and diverse biological activities.
  • These activities include anti-inflammatory, anticancer, antimicrobial, antimalarial, and insecticidal properties.

Purpose of the Study:

  • To comprehensively review natural eudesmane-type sesquiterpenoids isolated from 2016 to 2022.
  • To elucidate their chemical structures, plant distribution, and biological properties.
  • To provide a reference for future research on their pharmaceutical potential.

Main Methods:

  • Literature review of scientific databases for sesquiterpenoid isolation and identification.
  • Compilation and analysis of data on chemical structures, plant sources, and bioactivities.
  • Systematic cataloging of 391 eudesmane-type sesquiterpenoids.

Main Results:

  • A total of 391 eudesmane-type sesquiterpenoids were identified and reviewed.
  • Detailed information on their chemical structures and natural occurrence was compiled.
  • A wide spectrum of biological activities associated with these compounds was documented.

Conclusions:

  • Eudesmane-type sesquiterpenoids represent a significant class of natural products with broad bioactivity.
  • This review consolidates current knowledge, facilitating further investigation into their medicinal applications.
  • The findings support continued exploration of these compounds for drug discovery and development.