Related Experiment Video
Updated: Jun 15, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Cancer metastases: Tailoring the targets.
Manasi S Pote1, Deepshikha Singh1, Aparna M A1
1Department of Biotechnology, Savitribai Phule Pune University, Pune, Maharashtra, India.
Cancer metastasis, the spread of cancer cells, drives mortality. Understanding its mechanisms, including genetic factors and immune interactions, is key to developing effective anti-metastasis therapies and improving patient survival.
Area of Science:
- Oncology
- Cancer Biology
- Pathophysiology
Background:
- Cancer metastasis is the primary cause of cancer-related mortality.
- Current anti-metastasis therapies have limited success, highlighting the need for deeper mechanistic understanding.
- Cancer cell dissemination to distant organs requires complex biological processes.
Purpose of the Study:
- To provide a comprehensive review of the pivotal facets of cancer metastasis.
- To elucidate the intricate processes driving cancer invasiveness and colonization.
- To discuss current and potential therapeutic strategies targeting metastasis.
Main Methods:
- Literature review synthesizing current knowledge on cancer metastasis.
- Analysis of key processes including cancer cell homing, invasion, and angiogenesis.
- Examination of genetic, epigenetic, and immune-related mechanisms of metastasis.
Main Results:
- Metastasis involves complex steps: cancer cell dissemination, homing, invasion, angiogenesis, and pre-metastatic niche formation.
- Genetic, epigenetic factors, and microRNAs (miRNAs) play crucial roles in metastasis.
- Immune modulators and immune evasion strategies significantly impact metastatic progression.
Conclusions:
- A deeper understanding of metastasis mechanisms is essential for developing effective therapies.
- Targeting immune modulation presents promising therapeutic opportunities to arrest metastatic spread.
- Identifying novel therapeutic targets can disrupt the metastatic cascade and improve patient outcomes.
More Related Videos
10:32Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
Published on: December 19, 2019
07:41A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The Tumor Microenvironment
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer