Related Experiment Video
Updated: Jun 15, 2025
Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice
Published on: May 4, 2015
The prevalence of myocardial infarction in the elderly: A systematic review and meta-analysis
Fatemeh Rajati1, Mojgan Rajati2, Maryam Chegeni3
1Department of Health Promotion and Education, School of Health, Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermansha, Iran.
Insights
Myocardial infarction (MI) affects 17.6% of the elderly population. This systematic review highlights the increasing prevalence of MI with age, emphasizing the need for targeted prevention strategies in healthcare.
Area of Science:
- Cardiology
- Gerontology
- Public Health
Background:
- Myocardial infarction (MI) is myocardial cell death, with prevalence rising with age due to cardiovascular system changes.
- Elderly populations face increasing risks of MI, necessitating a comprehensive understanding of contributing factors.
Purpose of the Study:
- To systematically review and meta-analyze the prevalence of MI in the elderly.
- To standardize and resolve inconsistencies in existing MI prevalence data.
- To investigate factors influencing MI prevalence in older adults.
Main Methods:
- A systematic review and meta-analysis of studies published from 1987 to March 2022.
- Searched major databases (PubMed, Embase, Scopus, WoS) and Google Scholar.
- Quantified study heterogeneity using the I² index.
Main Results:
- Included 29 articles with 3,279,136 subjects; pooled MI prevalence was 17.6%.
- Prevalence was 16.1% in males and 12.5% in females.
- MI prevalence significantly increased with publication year and mean elderly age (P < 0.001).
Conclusions:
- High MI prevalence in the elderly requires integration into healthcare systems and policy.
- Increased attention to MI prevention strategies for the elderly is crucial.
- Pooled estimates should be interpreted cautiously due to study heterogeneity.
Background:
Myocardial Infarction (MI) refers to the destruction and death of cells in the myocardium of the heart. Its prevalence increases with age due to changes in the cardiovascular system. The aim of the present study was to combine, summarize, standardize, resolve inconsistencies in the results of studies, and investigate the impact of potential factors on the prevalence rate of MI in the elderly through a systematic review and meta-analysis.
Methods:
This systematic review and meta-analysis was conducted from 1987 to March 2022. All relevant published studies were searched in PubMed, Embase, Scopus, Web of Science (WoS) databases, and Google Scholar search engine using related MeSH/Emtree and Free Text words. The heterogeneity among studies was quantified using the I2 index.
Results:
In the initial search, 35453 studies were identified. After eliminating irrelevant studies, finally, 29 articles with a sample size of 3279136 subjects were included in the meta-analysis. After combining the results of the studies included in the meta-analysis, the total prevalence of MI in the elderly was estimated to be 17.6% (95% CI: 12.8 - 23.7%), 16.1% (95% CI: 11.0 - 22.8%) in males, and 12.5% (95% CI: 9.2 - 16.8%) in females. The prevalence of MI increased with the year of publication and the mean age of the elderly (P < 0.001).
Conclusion:
The results showed that due to the high prevalence of myocardial infarction (MI) in the elderly, it should be addressed within healthcare systems and policy makers should pay more attention to prevention of MI. However, considering the inclusion of heterogeneous studies, the pooled estimation should be interpreted with caution.
More Related Videos
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
Related Concept Videos
01:17Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
01:26Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...