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Ewing sarcoma of the uterus: A case report
Zeynep Tek1, Anya Laibangyang1, Oluwole Odujoko2
1Department of Obstetrics and Gynecology, Danbury and Norwalk Hospital, Nuvance Health, United States.
Case Reports in Women'S Health
|August 22, 2024
Summary
This case report details a rare instance of Ewing sarcoma in a 55-year-old woman's uterus. Aggressive multimodal treatment, including surgery and chemotherapy, led to no evidence of recurrent metastatic disease.
Area of Science:
- Gynecologic Oncology
- Oncology
- Pathology
Background:
- Ewing sarcoma is a rare bone and soft tissue cancer predominantly affecting adolescents.
- Uterine presentations of Ewing sarcoma are exceptionally rare, particularly with metastatic spread.
Observation:
- A 55-year-old woman presented with abdominal pain, abnormal uterine bleeding, and a large uterine mass.
- Imaging revealed a heterogeneous uterine mass concerning for sarcoma, with possible central necrosis.
Findings:
- Final pathology confirmed primary Ewing sarcoma-primitive neuroectodermal tumor of the uterus with peritoneal metastasis.
- The patient underwent complete surgical resection and 14 cycles of intensive chemotherapy (vincristine, doxorubicin, cyclophosphamide, ifosfamide, etoposide).
Implications:
- This case highlights an atypical presentation of Ewing sarcoma in the female genital tract.
- Successful multimodal treatment in this rare metastatic case offers insights for future management strategies.
- Further research into rare gynecologic sarcomas is crucial for improving patient outcomes.
