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Published on: August 20, 2019
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Human Aortic Stenotic Valve-Derived Extracellular Vesicles Induce Endothelial Dysfunction and Thrombogenicity Through
Sandy Hmadeh1, Antonin Trimaille1,2, Kensuke Matsushita1,2
1UR 3074 Translational Cardiovascular Medicine, CRBS, Strasbourg, France.
JACC. Basic to Translational Science
|August 22, 2024
Abstract:
Pathological tissues release a variety of factors, including extracellular vesicles (EVs) shed by activated or apoptotic cells. EVs trapped within the native pathological valves may act as key mediators of valve thrombosis. Human aortic stenosis EVs promote activation of valvular endothelial cells, leading to endothelial dysfunction, and proadhesive and procoagulant responses.
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