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Updated: Jun 15, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions
Xinyan Zou1, Xinfu Zou2, Longxia Gao1
1College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, China.
Alterations in gut microbiota contribute to psoriasis pathogenesis. Adjunct therapies like probiotics and diet can improve gut health and reduce inflammation in psoriasis patients.
Area of Science:
- Microbiology
- Immunology
- Dermatology
Background:
- Psoriasis is a common autoimmune skin disease.
- Microbiota alterations are increasingly implicated in psoriasis pathogenesis.
- Gut microbiota dysbiosis plays a role in various disease mechanisms.
Purpose of the Study:
- To review the link between microbial changes and psoriasis.
- To explore microbial-targeted therapies for psoriasis treatment.
- To assess the potential of prebiotics, probiotics, synbiotics, fecal microbiota transplantation, diet, and Traditional Chinese Medicine as adjunctive therapies.
Main Methods:
- Literature search conducted in PubMed and CNKI.
- Focused on studies investigating the relationship between psoriasis and gut microbiota.
Main Results:
- Adjunct therapies (diet, TCM, probiotics) enhance gut microbiota in psoriasis patients.
- These therapies modulate immune mediators like IL-23, IL-17, and IL-22.
- Inflammatory conditions are ameliorated by suppressing pro-inflammatory cytokines via pathways including NF-kB.
Conclusions:
- Future research should focus on intestinal microbiota and TCM mechanisms for psoriasis.
- Provides clinicians with comprehensive diagnostic and treatment options.
- Offers hope for improved patient outcomes in psoriasis management.
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