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Navigating the Challenges of Factor X Deficiency: A Case Study
Gaurav A Chaudhary1, Harin M Bhavsar1, Madhulika L Mahashabde1
1General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.
Cureus
|August 22, 2024
Summary
A rare Factor X deficiency caused severe bleeding in a 47-year-old female, highlighting the importance of diagnosing coagulopathies. Early detection of Factor X deficiency aids patient care and family screening.
Area of Science:
- Hematology
- Coagulation Science
Background:
- The coagulation cascade is essential for hemostasis, involving intrinsic and extrinsic pathways.
- Deficiencies in clotting factors disrupt this cascade, leading to bleeding disorders.
Observation:
- A 47-year-old female presented with epigastric pain and subsequent severe gum bleeding.
- The patient displayed abnormal prothrombin time (PT) and international normalized ratio (INR).
Findings:
- Diagnostic evaluation revealed Factor X (FX) deficiency as the cause of the patient's coagulopathy.
- Factor X deficiency impairs the common pathway of blood coagulation.
Implications:
- This case underscores the critical need for timely diagnosis of rare factor deficiencies like FX deficiency.
- Early diagnosis improves patient management and facilitates genetic screening for at-risk family members.
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