Correlation Between the Hepatitis C Virus NS3 Protein and CD30 Expression in Diffuse Large B-cell Lymphoma

Area of Science:

• Oncology
• Immunology
• Virology

Background:

• Non-Hodgkin lymphoma (NHL) pathogenesis can involve chronic infections like Hepatitis C Virus (HCV).
• Cluster of Differentiation 30 (CD30) expression is relevant for NHL treatment and prognosis.
• Elevated CD30 levels are observed in patients with HCV infection.

Purpose of the Study:

• To determine the prevalence of CD30 and HCV expression in Indonesian diffuse large B-cell lymphoma (DLBCL) patients.
• To investigate the correlation between CD30 and HCV expression and clinicopathological characteristics in DLBCL.

Main Methods:

• Analysis of 86 formalin-fixed paraffin-embedded (FFPE) DLBCL samples.
• Immunohistochemistry used to detect CD30 and HCV markers.
• Chi-square tests employed to assess correlations between CD30 expression and clinicopathological features.

Main Results:

• CD30 positivity rates were 25.6% (0% cut-off) and 7.0% (20% cut-off).
• HCV expression positivity rate was 34.9%.
• No statistically significant relationships were found between CD30/HCV expression and clinicopathological features (p>0.05).

Conclusions:

• No significant correlation exists between CD30 immunoreactivity or HCV NS3 expression and clinicopathological features in DLBCL.
• The study did not establish a link between these markers and patient characteristics like age, sex, or disease stage.