Related Experiment Video
Updated: Jun 15, 2025
13:28
Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
27.5K
Small airways in asthma: Pathophysiology, identification and management
Dimitrios Toumpanakis1,2, Omar S Usmani1
1National Heart and Lung Institute, Imperial College London, London, SW3 6LY, United Kingdom.
Chinese Medical Journal Pulmonary and Critical Care Medicine
|August 22, 2024
Summary
Small airway disease is a key factor in asthma, impacting control and exacerbations. Advanced assessment methods like oscillometry and nitrogen washout offer crucial insights for diagnosis and treatment.
Area of Science:
- Pulmonary Medicine
- Respiratory Research
- Asthma Pathophysiology
Background:
- Small airway disease is integral to asthma, involving inflammation, mucus, and remodeling.
- It contributes to airflow limitation and hyperresponsiveness, often missed by standard lung function tests.
Purpose of the Study:
- To review current evidence on small airway disease in asthma.
- Focus on pathophysiology, assessment techniques, and therapeutic implications.
Main Methods:
- Literature search using keywords: 'small airways', 'asthma', 'oscillometry', 'nitrogen washout', 'imaging'.
- Included studies on adult and pediatric asthma patients.
Main Results:
- Small airway dysfunction is prevalent in all asthma stages, particularly severe cases.
- Oscillometry and nitrogen washout are sensitive tools for detecting small airway disease.
- Small airway dysfunction correlates with asthma control and exacerbation frequency.
Conclusions:
- Assessing small airway disease offers vital information for asthma management.
- These assessments have potential therapeutic implications for guiding treatment and monitoring response.
Related Concept Videos
01:20Asthma: Pathogenesis and Management
376
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
376
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
01:30Asthma-IV: Nursing Management
3.0K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
3.0K
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:24Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K