Navigating the labyrinth of long non-coding RNAs in colorectal cancer: From chemoresistance to autophagy

Area of Science:

• Molecular Biology
• Oncology
• Genetics

Background:

• Long non-coding RNAs (lncRNAs) are key regulators in various biological processes, including cancer development.
• lncRNA expression significantly influences autophagy, a cellular process with a dual role in cancer initiation and progression.
• Aberrant lncRNA expression is linked to the development of chemoresistance in colorectal cancer (CRC).

Discussion:

• lncRNAs modulate autophagy, presenting a potential therapeutic target for overcoming chemoresistance in CRC.
• Recent studies highlight specific lncRNAs (TCONS_00014506 and PRNT) involved in CRC cell autophagy and oxaliplatin resistance.
• Intervening with lncRNAs that regulate autophagy is emerging as a novel strategy to enhance chemotherapeutic sensitivity in CRC.

Key Insights:

• lncRNAs play a critical role in regulating autophagy in colorectal cancer.
• Specific lncRNAs are associated with chemoresistance, particularly to oxaliplatin, in CRC.
• Modulating lncRNA-mediated autophagy can potentially reverse or overcome chemoresistance in CRC.

Outlook:

• Further research into lncRNA-autophagy interactions could uncover new therapeutic targets for CRC.
• Developing lncRNA-based strategies to modulate autophagy may improve treatment outcomes for chemoresistant CRC.
• This approach holds promise for personalized medicine in colorectal cancer treatment by targeting specific lncRNA pathways.