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Unveiling the role of long non-coding RNA MALAT1: a comprehensive review on myocardial infarction

Reza Eshraghi1, Sina Sadati1, Ashkan Bahrami1

  • 1Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.

Frontiers in Cardiovascular Medicine
|August 22, 2024
PubMed

Insights

Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) plays a key role in heart conditions like myocardial infarction (MI). Research explores MALAT1's function in cardiovascular health and its potential for diagnosing and treating MI complications.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Genomics

Background:

  • Myocardial infarction (MI) is a leading cause of death globally, often due to atherosclerosis and reduced coronary blood flow.
  • While reperfusion therapies improve outcomes, long-term management of MI remains challenging.
  • Long non-coding RNAs (lncRNAs) regulate gene expression in physiological and pathological conditions, including cardiovascular diseases.

Purpose of the Study:

  • To comprehensively evaluate the role of the lncRNA Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in myocardial infarction (MI).
  • To investigate MALAT1's involvement in cardiovascular processes such as autophagy, apoptosis, cell proliferation, and inflammation.
  • To explore MALAT1's potential as a diagnostic and therapeutic target for post-MI complications and ischemic reperfusion injury.

Main Methods:

  • Review of current scientific literature on MALAT1 and its functions in the cardiovascular system.
  • Analysis of studies investigating MALAT1's impact on heart function.
  • Examination of research on MALAT1's role in pathological processes relevant to MI.

Main Results:

  • MALAT1 is implicated in key cellular processes influencing cardiovascular health and disease.
  • Evidence suggests MALAT1 modulates pathways critical to the development and progression of MI.
  • The lncRNA's involvement in inflammation, apoptosis, and proliferation highlights its significance in cardiac injury.

Conclusions:

  • MALAT1 is a crucial regulator in the cardiovascular system with significant implications for myocardial infarction.
  • Understanding MALAT1's function offers potential for novel diagnostic and therapeutic strategies for MI and related injuries.
  • Further research into MALAT1 could lead to improved management of ischemic heart disease.

Keywords:
epigeneticlong non-coding RNAmetastasis associated lung adenocarcinoma transcript 1myocardial infarctionpathology

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