Related Experiment Video

Updated: Jun 15, 2025

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.0K

APOL1 polymorphisms are not influencing acute coronary syndrome risk in Czech males

Jaroslav A Hubacek1,2, Vera Adamkova3, Vera Lanska4

  • 1Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Molecular Genetics & Genomic Medicine
|August 22, 2024
PubMed

Insights

Apolipoprotein L1 (APOL1) genetic variations do not significantly increase the risk of acute coronary syndrome (ACS) in Caucasian men. This study found no association between APOL1 polymorphisms and ACS or cardiovascular mortality.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) is a leading global cause of death, influenced by genetic and environmental factors.
  • Apolipoprotein L1 (APOL1) gene variations are linked to ASCVD risk in African populations, but their role in other ethnicities is unclear.

Purpose of the Study:

  • To investigate the association between APOL1 genetic polymorphisms and the risk of acute coronary syndrome (ACS) in a Caucasian male cohort.
  • To determine if APOL1 variability influences traditional cardiovascular disease risk factors or mortality.

Main Methods:

  • Genotyping of four specific APOL1 polymorphisms (rs13056427, rs136147, rs10854688, rs9610473) in 1541 male patients with ACS and 1338 male controls.
  • Analysis of associations with traditional cardiovascular risk factors (smoking, hypertension, diabetes, BMI, lipid levels).
  • Longitudinal follow-up for total and cardiovascular mortality over approximately 10 years.

Main Results:

  • No significant association was found between individual APOL1 polymorphisms and traditional cardiovascular disease risk factors.
  • Neither individual APOL1 polymorphisms nor their haplotypes were linked to an increased risk of ACS.
  • APOL1 variations did not predict total or cardiovascular mortality during the follow-up period.

Conclusions:

  • APOL1 genetic variability does not appear to be a major risk factor for ACS in the studied Caucasian male population.
  • The findings suggest a limited role for APOL1 in ASCVD pathogenesis among Caucasians.
Abstract

Keywords:
Caucasiansapolipoprotein L1cardiovascular diseasemortalitypolymorphism

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.2K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.8K

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.9K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
27
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
68
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
549
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.2K
Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
464