Influence of Single Nucleotide Polymorphisms on CRS Outcomes: A Preliminary Observational Study
Antonino Maniaci1,2,3, Paolo Bonacci4, Stefania Stefani3
1Faculty of Medicine and Surgery, University of Enna "Kore", Enna, Italy.
The Laryngoscope
|August 22, 2024
Summary
Single nucleotide polymorphism (SNP) genotypes may help personalize treatment for chronic rhinosinusitis (CRS). Specific SNP variants correlated with better outcomes in patients receiving dupilumab therapy or surgery.
Area of Science:
- Otolaryngology
- Genetics
- Immunology
Background:
- Chronic rhinosinusitis (CRS) is a complex inflammatory condition.
- Understanding the genetic basis of CRS can inform treatment strategies.
Purpose of the Study:
- To investigate the association between specific single nucleotide polymorphism (SNP) variants and treatment outcomes in CRS patients.
- To evaluate the effectiveness of dupilumab therapy and endoscopic surgery in relation to SNP profiles.
Main Methods:
- Prospective study of 48 subjects (32 CRS patients, 16 controls).
- CRS patients received either dupilumab or surgery.
- SNP genotyping performed using TaqMan.
- Treatment response assessed via symptom scores (SNOT-22), Nasal Polyp Score (NPS), and Smell Identification Test (SIT) at 6 months.
Main Results:
- Both dupilumab and surgery reduced NPS, with surgery showing superior results.
- Dupilumab significantly improved SIT scores.
- Significant differences in SNP profiles (rs1800629, rs2856838, rs17561, rs1805011) were observed.
- Expression of rs2856838 and rs1805011 variants correlated with better SIT and SNOT-22 outcomes in the dupilumab group.
- rs2856838 expression in the surgery group was linked to improved SNOT-22 scores.
Conclusions:
- Preliminary findings suggest SNP genotypes can guide personalized CRS treatment.
- Larger prospective studies are needed to validate these results.
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