Related Experiment Video
Updated: Jun 25, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
4.4K
Navigating the Nexus: Acute Kidney Injury in Acute Stroke - A Prospective Cohort Study
Sameer Arora1, Arpit Agrawal2, Venugopalan Y Vishnu3
1Department of Neurology, Narayana Hospital, Gurugram, Haryana, India.
Annals of Indian Academy of Neurology
|August 22, 2024
Summary
Acute kidney injury (AKI) is common in stroke patients and significantly increases hospital mortality. Further research is needed to determine if preventing AKI can reduce stroke-related deaths.
Area of Science:
- Nephrology
- Neurology
- Critical Care Medicine
Background:
- Acute kidney injury (AKI) is a frequent complication in patients experiencing acute stroke.
- Limited data exists on the incidence of AKI and its impact on stroke patient outcomes.
Purpose of the Study:
- To determine the prevalence of AKI in patients with acute ischemic stroke and intracerebral hemorrhage.
- To investigate the association between AKI and clinical outcomes, including mortality, in stroke patients.
Main Methods:
- A prospective observational study included 204 patients with acute stroke (ischemic or hemorrhagic).
- AKI was defined as a serum creatinine increase of ≥0.3 mg/dL within 48 hours or ≥50% from baseline within 7 days.
- Multivariate logistic regression analyzed the relationship between AKI and hospital mortality, adjusting for covariates.
Main Results:
- AKI occurred in 34% of ischemic stroke and 66.7% of intracerebral hemorrhage cases.
- AKI was significantly associated with increased hospital mortality in both ischemic stroke (OR 27.21) and hemorrhagic stroke (OR 5.12).
- Intracranial hemorrhage patients had a higher mortality rate (36.7%) compared to ischemic stroke patients (8.3%).
Conclusions:
- AKI is a frequent complication of stroke and is independently associated with higher hospital mortality.
- Further research is warranted to explore a potential causal relationship and the efficacy of AKI prevention strategies in reducing stroke-related mortality.
Related Concept Videos
01:22Acute Kidney Injury I: Introduction
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
01:29Acute Kidney Injury II: Pathophysiology
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
01:29Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:20Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
01:22Acute Kidney Injury VI: Nursing Management
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...