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Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

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[Dengue encephalitis in Argentina].

Melany Berdiñas Anfuso¹, María Victoria Gonzalez¹, Sofía Schverdfinger¹

¹Servicio de Terapia Intensiva de Adultos, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

|August 22, 2024

Summary

Dengue encephalitis, a severe neuroinvasive manifestation of dengue virus, is often underdiagnosed due to varied symptoms and normal neuroimaging. This study highlights three cases in Argentina with positive PCR confirming dengue encephalitis despite non-specific findings.

Keywords:

dengue dengue encephalitis neurological symptoms viral encephalitis

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Area of Science:

Neurology
Infectious Diseases
Virology

Background:

Dengue virus, endemic in Argentina, is increasingly recognized as neuroinvasive.
Neurological manifestations affect up to 15% of dengue patients, with encephalitis being severe but often underdiagnosed.

Observation:

Three cases of dengue encephalitis were diagnosed at a Buenos Aires university hospital.
Clinical presentations varied from disorientation to refractory seizures.
Cerebrospinal fluid analysis showed diverse results, but all cases had positive dengue PCR.

Findings:

Dengue encephalitis diagnosis can be challenging due to non-specific and varied clinical and cerebrospinal fluid findings.
Neuroimaging was normal in all presented cases, underscoring its limitations in diagnosing dengue encephalitis.
Positive dengue PCR in cerebrospinal fluid confirmed the diagnosis despite atypical presentations.

Implications:

Increased clinical suspicion for dengue encephalitis is crucial, especially in endemic areas.
Diagnostic strategies should consider PCR in cerebrospinal fluid when encephalitis is suspected.
Further research is needed to improve early detection and management of dengue encephalitis.