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Multiscale modeling shows how 2'-deoxy-ATP rescues ventricular function in heart failure.

Abigail E Teitgen1, Marcus T Hock1, Kimberly J McCabe2

  • 1Department of Bioengineering, University of California San Diego, La Jolla, CA 92093.

Proceedings of the National Academy of Sciences of the United States of America
|August 22, 2024
PubMed
Summary
This summary is machine-generated.

2'-deoxy-ATP (dATP) enhances cardiac function by boosting crossbridge cycling. Even small amounts of dATP significantly improve heart contractility and efficiency, particularly in heart failure models.

Keywords:
cardiac functiondATPmultiscale modelingmyosinsarcomere

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Area of Science:

  • Cardiovascular Physiology
  • Biophysics
  • Computational Biology

Background:

  • 2 -deoxy-ATP (dATP) is known to improve cardiac function, but the underlying mechanisms and therapeutic efficacy at low concentrations are unclear.
  • Understanding how dATP modulates cardiac contractility is crucial for developing treatments for heart failure.

Purpose of the Study:

  • To elucidate the multiscale mechanisms by which dATP improves ventricular function.
  • To investigate how small fractions of dATP enhance cardiac performance from molecular to organ levels.

Main Methods:

  • Utilized a multiscale computational modeling approach, integrating atomistic simulations, Markov state modeling, and organ-scale simulations.
  • Analyzed actomyosin association, sarcomere mechanics, myocyte Ca[Formula: see text] dynamics, and biventricular mechanoenergetics.

Main Results:

  • dATP significantly increased the actomyosin association rate (1.9-fold) and the pool of myosin heads available for crossbridge cycling.
  • Mechanosensing and cooperativity were identified as key mechanisms for dATP's effect at low fractions, increasing force development (1.3-fold).
  • In a heart failure model, dATP improved ejection fraction by 16% and energy efficiency by 1%.

Conclusions:

  • Small amounts of dATP can substantially enhance cardiac contractility through increased crossbridge cycling efficiency and improved Ca[Formula: see text] handling.
  • This study provides a comprehensive multiscale analysis of dATP's mechanism of action, offering insights into potential therapeutic strategies for heart failure.