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Related Experiment Videos

Natural progesterone and antihypertensive action.

P B Rylance, M Brincat, K Lafferty

    British Medical Journal (Clinical Research Ed.)
    |January 5, 1985
    PubMed
    Summary

    Natural progesterone significantly reduced blood pressure in men and postmenopausal women with hypertension. This finding suggests a potential antihypertensive effect of progesterone, warranting further investigation into its protective role.

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    Area of Science:

    • Endocrinology
    • Cardiovascular Medicine
    • Pharmacology

    Background:

    • Hypertension is a prevalent cardiovascular condition with significant health implications.
    • The role of sex hormones, including progesterone, in blood pressure regulation is not fully understood.
    • Previous research has yielded conflicting results regarding progesterone's effect on blood pressure.

    Purpose of the Study:

    • To investigate the effect of orally administered natural progesterone on blood pressure in individuals with hypertension.
    • To determine if progesterone exhibits an antihypertensive or hypertensive action in this population.

    Main Methods:

    • A placebo-controlled, double-blind crossover study design was employed.
    • Six men and four postmenopausal women with mild to moderate hypertension participated.

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  • Participants received increasing doses of natural progesterone orally, with placebo periods for comparison.

    • Main Results:

    • Natural progesterone administration resulted in a significant reduction in blood pressure compared to baseline and placebo.
    • No hypertensive effects were observed; instead, a notable decrease in blood pressure was documented.
    • The findings indicate a potential antihypertensive property of progesterone.

    Conclusions:

    • Natural progesterone demonstrates a significant blood pressure-lowering effect in individuals with hypertension.
    • This study challenges previous notions of progesterone having a hypertensive action.
    • Further research is recommended to explore the potential protective cardiovascular effects of progesterone.