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Causal relationship between OHSS and immune cells: A Mendelian randomization study.

Hai-Ming Zhang1, Bo Yao2, Li Li1

  • 1Department of Histology and Embryology, School of Preclinical Medical, Zunyi Medical University, Zunyi, Guizhou, China.

Journal of Reproductive Immunology
|August 22, 2024
PubMed
Summary

This Mendelian randomization study reveals a genetic link between specific immune cell phenotypes and Ovarian Hyperstimulation Syndrome (OHSS). Findings suggest immune cells may play a causal role in OHSS development.

Keywords:
Causal inferenceImmune cellMendelian randomizationOHSS

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Area of Science:

  • Immunology
  • Genetics
  • Reproductive Medicine

Background:

  • Ovarian Hyperstimulation Syndrome (OHSS) is a serious complication of assisted reproductive technologies.
  • The precise causal factors, particularly the role of immune cells, remain incompletely understood.

Purpose of the Study:

  • To investigate the potential causal relationship between various immune cell phenotypes and the risk of developing OHSS.
  • To explore bidirectional causality between immune cells and OHSS using genetic data.

Main Methods:

  • A two-sample Mendelian randomization study design was employed.
  • Utilized genome-wide association study (GWAS) data for immune cell phenotypes (22 million SNPs) and OHSS.
  • Applied inverse variance weighting, MR-Egger, and weighted median methods to assess causality.

Main Results:

  • Nine distinct immunophenotypes showed a statistically significant association with OHSS risk after False Discovery Rate correction.
  • Significant associations were observed across B cell, mature T cell, myeloid cell, monocyte, and conventional dendritic cell panels.
  • Specific cell markers and their odds ratios (OR) indicate varying degrees of association with OHSS risk.

Conclusions:

  • This genetic study provides evidence for a potential causal link between specific immune cell profiles and OHSS.
  • The findings offer novel insights for future clinical and basic research into OHSS pathogenesis and potential therapeutic targets.