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Is there a role for intestinal sporobiota in the antimicrobial resistance crisis?

A Romero-Rodríguez1, B Ruíz-Villafán2, S Sánchez2

  • 1Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, Ciudad de México 04510, Mexico.

Microbiological Research
|August 22, 2024
PubMed

Insights

Antimicrobial resistance (AMR) spreads via resistant bacteria, fueled by antimicrobial use. The gut sporobiota resistome is a key factor in tracking and limiting the spread of these resistance genes.

Area of Science:

  • Microbiology
  • Public Health
  • Environmental Science

Background:

  • Antimicrobial resistance (AMR) is a growing global health threat.
  • The use, misuse, and overuse of antimicrobials drive the development of resistant bacteria and resistance genes.
  • Socioeconomic and environmental factors significantly influence AMR transmission.

Purpose of the Study:

  • To highlight the role of the sporobiota in the gut microbiota.
  • To investigate the sporobiota's potential as a vector for AMR.
  • To emphasize the importance of the sporobiota resistome in managing AMR.

Main Methods:

  • Review of existing literature on antimicrobial resistance and gut microbiota.
  • Analysis of the sporobiota's characteristics, including transmissibility and spore formation.
  • Examination of the mobile resistome within the sporobiota.

Main Results:

  • Antimicrobial selective pressure promotes the development of "silent" reservoirs of resistance genes.
  • Spores, due to their high transmissibility, can act as vectors for AMR.
  • The sporobiota resistome, especially mobile elements, harbors genes that can spread AMR.

Conclusions:

  • The sporobiota plays a crucial role in the gut ecosystem and can contribute to AMR.
  • Understanding and monitoring the sporobiota resistome is vital for controlling AMR.
  • Targeting the sporobiota may offer novel strategies for combating antimicrobial resistance.
Keywords:
AntibioticsAntimicrobial resistanceMicrobiomesOne HealthSpore

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