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Updated: Jun 15, 2025

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
Published on: January 26, 2024
Rationally reprogramming single-cell aging trajectories and lifespan through dynamic modulation of environmental
Matthew Smart1, David F Moreno2, Murat Acar3
1Center for Computational Biology, Flatiron Institute, New York, NY, USA.
Abstract:
How do variations in nutrient levels influence cellular lifespan? A dynamical systems model of a core circuit involved in yeast aging suggests principles underlying lifespan extension observed at static and alternating glucose levels that are reminiscent of intermittent fasting regimens.
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