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Related Concept Videos

Phosphoinositides and PIPs01:42

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Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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Updated: Jun 15, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Obstetric antiphospholipid syndrome.

Adriana Soto-Peleteiro1, Cristina Gonzalez-Echavarri1, Guillermo Ruiz-Irastorza2

  • 1Autoimmune Diseases Research Unit, Department of Internal Medicine, Biobizkaia Health Research Institute, Hospital Universitario Cruces, Spain.

Medicina Clinica
|August 22, 2024
PubMed
Summary
This summary is machine-generated.

Antiphospholipid syndrome (APS) management during pregnancy requires early medical-obstetric coordination. Treatment involves low-dose aspirin and potentially low-molecular-weight heparin to prevent pregnancy complications.

Keywords:
AbortoAnticardiolipinAnticardiolipinaAnticoagulante lúpicoAnticuerpos antifosfolípidoAntiphospholipid antibodiesAspirinaFetal lossHeparinHeparinaHidroxicloroquinaHydroxychloroquineLow-dose aspirinLupus anticoagulantMiscarriageMuerte fetalPreeclampsia

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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Area of Science:

  • Obstetrics and Gynecology
  • Rheumatology
  • Hematology

Background:

  • Antiphospholipid syndrome (APS) is a primary autoimmune thrombophilia.
  • APS significantly increases risks for adverse pregnancy outcomes, including miscarriage and placental dysfunction.
  • Effective management is crucial for improving maternal and fetal health in APS pregnancies.

Purpose of the Study:

  • To outline essential management strategies for obstetric Antiphospholipid syndrome (APS).
  • To emphasize the importance of preconceptional counseling and risk assessment.
  • To detail therapeutic approaches for APS during pregnancy and postpartum.

Main Methods:

  • Review of current literature and clinical guidelines for obstetric APS management.
  • Emphasis on a multidisciplinary approach involving medical and obstetric specialists.
  • Discussion of pharmacological interventions and delivery timing considerations.

Main Results:

  • Preconceptional visits are vital for risk stratification and therapy adjustment.
  • Low-dose aspirin combined with low-molecular-weight heparin is the cornerstone of APS pregnancy management.
  • Routine induction of labor is not recommended unless complications arise.

Conclusions:

  • Coordinated medical-obstetric care, starting preconceptually, is essential for managing APS in pregnancy.
  • Personalized therapeutic strategies improve outcomes for pregnancies affected by APS.
  • Postpartum management is a critical component of comprehensive APS care.