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Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS
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Published on: October 7, 2009

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Antiphospholipid antibody testing.

Savino Sciascia1, Barbara Montaruli2, Maria Infantino3

  • 1University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-Reconnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hub Hospital, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.

Medicina Clinica
|August 22, 2024
PubMed
Summary
This summary is machine-generated.

Antiphospholipid antibodies (aPL) are key indicators for antiphospholipid syndrome (APS). Laboratory tests for aPL are vital for assessing risks and diagnosing APS, guiding patient management effectively.

Keywords:
Anti-beta-2 glycoprotein I antibodiesAnticardiolipin antibodiesAnticoagulante lúpicoAnticuerpo antifosfolípidoAnticuerpos anti-beta-2 glicoproteína IAnticuerpos anticardiolipinaAntiphospholipid antibodyAntiphospholipid antibody testingLupus anticoagulantPruebas de anticuerpos antifosfolípidos

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Area of Science:

  • Immunology
  • Clinical Pathology
  • Autoimmunity

Background:

  • Antiphospholipid antibodies (aPL) are autoantibodies targeting phospholipid-binding proteins.
  • These antibodies are associated with antiphosphospholipid syndrome (APS) and other clinical conditions.
  • aPLs are linked to adverse outcomes including thrombosis and obstetric complications.

Purpose of the Study:

  • To provide an overview of laboratory tests for measuring aPL.
  • To discuss the clinical implications of aPL detection.
  • To highlight the importance of aPL testing in APS diagnosis and risk assessment.

Main Methods:

  • Review of available laboratory diagnostic assays for aPL.
  • Includes solid-phase immunological assays and functional clotting assays (lupus anticoagulants).

Main Results:

  • Specific aPL identified and reactivity patterns correlate with disease severity.
  • Laboratory testing is crucial for risk evaluation and APS classification criteria.
  • Various assays exist for detecting aPL, each with specific applications.

Conclusions:

  • Laboratory testing for aPL is essential for diagnosing and managing APS.
  • Understanding aPL test results aids in predicting patient outcomes.
  • Accurate aPL detection supports clinical decision-making in relevant medical settings.