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Updated: Jun 15, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Social determinants of perinatal mental health
Christina Pardo1, Breanna Watson2, Olga Pinkhasov3
1Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Insights
Social inequities significantly impact perinatal mental health. The Urban Stress Model explains how urban living conditions increase risks, highlighting the need for culturally sensitive interventions to address these disparities.
Area of Science:
- Public Health
- Mental Health Research
- Sociology
Background:
- Social inequities and mental health are intertwined public health issues.
- Perinatal mental health is affected by social, physical, biological factors, and pregnancy-related stressors.
- Social determinants of health (SDOH) include living conditions and cultural norms impacting diverse populations.
Purpose of the Study:
- To understand how SDOH influences perinatal mental health.
- To introduce the Urban Stress Model linking urban realities to stress and adverse perinatal mental health outcomes.
- To highlight the importance of cultural considerations in screening and interventions for diverse communities.
Main Methods:
- Introduction of the Urban Stress Model.
- Description of mechanisms linking urban living to stress response.
- Application of a structural determinants of health framework.
Main Results:
- Urban living conditions are linked to increased risk of adverse perinatal mental health.
- Cultural considerations are crucial for effective interventions in diverse ethnic groups.
- Interventions can be developed at policy and community levels.
Conclusions:
- Addressing social inequities is essential for improving perinatal mental health outcomes.
- The Urban Stress Model provides a framework for understanding these complex relationships.
- Culturally tailored interventions are necessary to mitigate the impact of SDOH on perinatal mental health.
Abstract:
Social inequities and mental health are public health and medical conditions that are inextricably linked. Perinatal mental health is influenced by social, physical, and biological factors, with additional stressors related to pregnancy. The social determinants of health (SDOH) encompasses all conditions in which people live and grow, inclusive of cultural norms that reflect the diverse populations we serve. To best understand the mechanisms by which the SDOH affects perinatal mental health, we introduce the Urban Stress Model and describe the link between urban realities to stress response and potential mechanisms that link urban living to increased risk of adverse perinatal mental health. Given the increased diversity of patient populations, cultural considerations are paramount in understanding the utility and best practices in screening and interventions among ethnically diverse communities. Building on our Urban Stress Model and a structural determinants of health framework, we present examples of interventions to address the social inequities of perinatal mental health from the policy to community levels.
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