[Enzyme metabolism and functions in vitamin biosynthesis pathways]

Area of Science:

• Biochemistry
• Metabolic Engineering

Background:

• Vitamins are essential organic compounds vital for life activities, synthesized through complex metabolic networks involving numerous enzymes.
• Current understanding of key enzyme properties in vitamin biosynthesis is limited, hindering efficient vitamin production and biotechnological advancements.

Purpose of the Study:

• To comprehensively review enzymes involved in 13 vitamin biosynthesis pathways.
• To detail enzymatic properties, catalytic mechanisms, and biological applications.
• To explore the potential of deep learning in vitamin biosynthesis research.

Main Methods:

• Literature review of enzymes in 13 vitamin synthesis pathways.
• Comparative analysis of vitamin synthesis enzymes with those in the glycolysis pathway.
• Discussion on the application of deep learning methods for enzyme property research.

Main Results:

• Detailed review of catalytic mechanisms, kinetic properties, and applications of enzymes in 13 vitamin synthesis pathways.
• Comparison of enzyme characteristics, including catalytic efficiency and substrate affinity, between vitamin metabolism and glycolysis pathways.
• Identification of research gaps and limitations in understanding enzyme properties for vitamin production.

Conclusions:

• Enzyme properties are critical for understanding and optimizing vitamin biosynthesis.
• Comparative analysis reveals unique characteristics of enzymes in vitamin synthesis pathways.
• Deep learning offers promising avenues for advancing research on vitamin biosynthesis enzymes and enhancing production.