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Updated: Jun 15, 2025

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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The Rubicon-WIPI axis regulates exosome biogenesis during ageing

Kyosuke Yanagawa1,2, Akiko Kuma1,3, Maho Hamasaki1,4

  • 1Department of Genetics, Graduate School of Medicine, Osaka University, Suita, Japan.

Nature Cell Biology
|August 22, 2024
PubMed
Summary

The Rubicon-WIPI pathway regulates exosome release and biogenesis. This pathway influences cellular senescence and longevity by controlling exosome microRNA content and quantity, particularly with aging.

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