Prognostic nutritional index predicts lateral lymph node metastasis and recurrence free survival in papillary thyroid carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.The prognostic nutritional index (PNI) can predict recurrence-free survival and lymph node metastasis in papillary thyroid carcinoma (PTC) patients. Lower PNI indicates poorer survival and is linked to advanced disease stages.
Area Of Science
- Oncology
- Hematology
- Surgical Pathology
Background
- Preoperative hematological parameters predict outcomes in many cancers.
- Limited research exists on preoperative indicators for papillary thyroid carcinoma (PTC).
- This study investigates the prognostic nutritional index (PNI) in PTC.
Purpose Of The Study
- To identify preoperative indicators associated with recurrence-free survival (RFS) in PTC patients.
- To explore the clinical impact of PNI on lymph node metastasis and RFS in PTC.
Main Methods
- Retrospective review of 619 PTC patients (Jan 2013-Dec 2017).
- Analysis of laboratory values, including PNI calculation and cutoff determination via ROC curves.
- COX proportional hazard and Kaplan-Meier analyses for RFS; logistic regression for lymph node metastasis prediction.
Main Results
- Age, PNI, and lymph node metastasis were independent prognostic indicators for RFS.
- Lower PNI and age >55 years correlated with poorer RFS.
- Low PNI was associated with age, sex, extrathyroidal invasion, T, N, and TNM stages; PNI uniquely predicted lateral lymph node metastasis.
Conclusions
- PNI is a promising preoperative hematological indicator for RFS in PTC.
- PNI effectively predicts lateral lymph node metastasis in PTC patients.
- PNI offers valuable prognostic information for PTC management.
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