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Updated: Jun 15, 2025

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
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Vision Loss and Substance Misuse: A Systematic Review.

Amber Prater1, Amanda Hinson-Enslin1, Heather McClintock2

  • 1Department of Population and Public Health Sciences, Wright State Boonshoft School of Medicine, Fairborn, Ohio, USA.

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Substance use may increase the risk of vision loss, according to a review of U.S. literature. Healthcare providers should screen at-risk patients for vision problems to prevent further disability.

Keywords:
Vision lossalcohol usedrug usesensory disabilitysubstance use

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Area of Science:

  • Public Health
  • Ophthalmology
  • Addiction Medicine

Background:

  • Rising rates of sensory disabilities and substance use in the U.S. highlight a need to understand their relationship.
  • Existing literature has not fully elucidated the connection between substance use and vision loss.
  • This review focuses on the U.S. population, examining current research on substance use and vision impairment.

Purpose of the Study:

  • To systematically review and assess the relationship between substance use and vision loss in the United States.
  • To synthesize findings from current literature regarding this association.
  • To identify potential risk factors and areas for future research.

Main Methods:

  • A comprehensive literature search was conducted across major databases (MEDLINE, APA PsycINFO, Web of Science, EBSCO, CINAHL).
  • Studies published in English between 2010 and 2022, focusing on U.S. populations, were included.
  • The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol guided the review process, with risk of bias assessed by study design.

Main Results:

  • Twenty-one articles, encompassing 89,132 patients, were included in the analysis.
  • Nineteen studies reported a positive association between vision loss and substance use.
  • Fifteen studies indicated that substance use is a significant risk factor for developing vision loss.

Conclusions:

  • Findings suggest a potential causal link between substance use and vision loss.
  • Recommendations include screening at-risk patients for vision loss to mitigate disability.
  • Further research is required to confirm substance use as a risk factor and explore the impact of vision loss on substance use patterns.