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Updated: Jun 15, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

825

Mortality outcomes in individuals with MASLD versus MASLD and increased alcohol intake

Majd B Aboona1, Pojsakorn Danpanichkul2,3, Vincent L Chen4

  • 1University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, USA.

Journal of Gastroenterology and Hepatology
|August 23, 2024
PubMed
Abstract

Insights

Metabolic dysfunction-associated steatotic liver disease (MASLD) patients with increased alcohol intake (MetALD) face a higher risk of cancer mortality compared to MASLD alone. Accurate alcohol assessment is crucial for managing MASLD and MetALD patients.

Area of Science:

  • Hepatology
  • Internal Medicine
  • Public Health

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern.
  • Metabolic dysfunction-associated steatotic liver disease with alcohol intake (MetALD) is a newly described entity.
  • The comparative natural history of MetALD and MASLD remains largely unknown.

Purpose of the Study:

  • To compare the longitudinal health outcomes of patients with MASLD versus MetALD.
  • To investigate differences in overall, cardiovascular, cancer-related, and other mortality causes between MASLD and MetALD cohorts.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (2011-2018).
  • Defined MASLD using the United States Fatty Liver Index (>30) and cardiometabolic criteria.
  • Defined MetALD as MASLD with specific daily alcohol intake thresholds for males and females.

Main Results:

  • Included 2838 MASLD and 2557 MetALD patients with a median follow-up of 56 months.
  • MetALD patients exhibited a significantly increased risk of cancer-related mortality (HR 1.32; P < 0.01).
  • No significant differences were observed in overall, cardiovascular, or other causes of mortality between the groups.

Conclusions:

  • MetALD patients demonstrate a higher risk for cancer-related mortality compared to MASLD patients.
  • Emphasizes the need for vigilant cancer surveillance in MASLD patients.
  • Highlights the importance of accurately classifying alcohol consumption for improved patient outcomes.
Keywords:
Alcohol useCancerMortalityNHANES

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