Related Experiment Video
Updated: Jun 15, 2025
07:34
Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
Published on: December 16, 2022
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Time-restricted eating, the clock ticking behind the scenes
Aleix Ribas-Latre1,2,3, Sonia Fernández-Veledo1,2,3, Joan Vendrell1,2,3
1Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari de Tarragona, Tarragona, Spain.
Frontiers in Pharmacology
|August 23, 2024
Summary
Time-restricted eating (TRE) shows promise for metabolic health in obesity. This review explores TRE
Area of Science:
- Metabolic Health
- Obesity Research
- Nutritional Science
Background:
- Metabolic balance requires nutrient cycling between feeding and fasting periods.
- Obesity and metabolic disorders are linked to impaired nutrient regulation.
- Caloric restriction (CR) and intermittent fasting (IF) are strategies to improve metabolic health.
Purpose of the Study:
- To review the metabolic effects of various intermittent fasting (IF) methods, focusing on time-restricted eating (TRE).
- To synthesize current knowledge on TRE's impact on obesity and metabolic health, considering chronotype and circadian rhythms.
- To identify research gaps in TRE interventions.
Main Methods:
- Narrative review methodology.
- Systematic literature search of pre-clinical and clinical studies.
- Keywords included: Obesity, Intermittent Fasting, Time-restricted eating, Chronotype, Circadian rhythms.
Main Results:
- TRE interventions show metabolic benefits in overweight, obese, and type II diabetic individuals.
- Animal models highlight the circadian clock's role in mitigating obesity-induced metabolic disturbances with time-restricted feeding (TRF).
- TRE can modulate the microbiota, influencing circadian rhythms.
Conclusions:
- TRE is a promising IF strategy for improving metabolic health and managing obesity.
- Individual chronotype plays a crucial role in TRE efficacy, often overlooked in practice.
- The interplay between the circadian clock, microbiota, and TRE warrants further investigation.
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