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S100a8/A9 proteins: critical regulators of inflammation in cardiovascular diseases

Yu Sun1, Han Xu2, Weihan Gao2

  • 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Frontiers in Cardiovascular Medicine
|August 23, 2024
PubMed

Insights

Neutrophil hyperexpression indicates inflammation and cardiovascular disease risk. S100 calcium binding protein A8/A9 (S100A8/A9) shows promise as a biomarker and therapeutic target for these conditions.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Biology
  • Biomarker Discovery

Background:

  • Neutrophil activation and hyperexpression are critical in inflammatory processes.
  • This heightened neutrophil activity is linked to the development of various cardiovascular disorders.
  • S100 calcium binding protein A8/A9 (S100A8/A9), originating from neutrophils, is emerging as a significant indicator for cardiovascular disease.

Purpose of the Study:

  • To evaluate the potential of S100A8/A9 as a diagnostic biomarker for cardiovascular diseases.
  • To assess S100A8/A9 as a therapeutic target for cardiovascular conditions.
  • To analyze the structural and biological characteristics of S100A8/A9 in relation to cardiovascular health.

Main Methods:

  • Review of existing literature on S100A8/A9.
  • Analysis of S100A8/A9's role in atherosclerosis.
  • Investigation of S100A8/A9's impact on myocardial infarction and ischemia/reperfusion injury.
  • Assessment of S100A8/A9's involvement in heart failure.

Main Results:

  • S100A8/A9 exhibits significant potential as a biomarker for cardiovascular disease diagnosis.
  • The protein's biological properties suggest its utility as a therapeutic target.
  • S100A8/A9 influences key cardiovascular conditions, including atherosclerosis, myocardial infarction, and heart failure.

Conclusions:

  • S100A8/A9 is a promising biomarker for diagnosing cardiovascular diseases.
  • Targeting S100A8/A9 may offer novel therapeutic strategies for cardiovascular conditions.
  • Understanding S100A8/A9's role is crucial for managing inflammation-related cardiovascular disorders.

Keywords:
S100A8/A9 proteinbiomarkercardiovascular diseaseinflammationneutrophil

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