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Association between Ureaplasma urealyticum colonization and bronchopulmonary dysplasia in preterm infants: a

Xianhong Chen1, Xunbin Huang2, Qiujing Zhou2

  • 1Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.

Frontiers in Pediatrics
|August 23, 2024
PubMed

Insights

Ureaplasma urealyticum (UU) colonization is linked to bronchopulmonary dysplasia (BPD) in preterm infants. Further high-quality trials are needed to confirm this association and guide clinical strategies for improving infant outcomes.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a leading chronic lung disease in premature infants.
  • Ureaplasma urealyticum (UU) infection is implicated in BPD pathogenesis, but its role remains debated.
  • Understanding the association between UU and BPD is crucial for neonatal care.

Purpose of the Study:

  • To systematically review and meta-analyze the correlation between UU colonization and BPD in preterm infants.
  • To synthesize current evidence on the impact of UU on BPD development.
  • To inform clinical practice and future research directions.

Main Methods:

  • Comprehensive literature search across multiple databases up to March 2024.
  • Inclusion of cohort and case-control studies following PRISMA guidelines.
  • Random-effects meta-analysis with assessment of heterogeneity, subgroup analyses, and publication bias.

Main Results:

  • Analysis of 36 cohort studies with 5,991 participants.
  • Significant association found between UU colonization and BPD at 28 days (OR: 2.26) and 36 weeks postmenstrual age (OR: 2.13).
  • Evidence quality was rated as very low, highlighting the need for further investigation.

Conclusions:

  • A correlation exists between UU colonization and BPD development in preterm infants.
  • High-quality randomized controlled trials are essential to establish causality and refine screening/prevention strategies.
  • Improved understanding can lead to better outcomes for neonates affected by BPD.
Abstract

Keywords:
Ureaplasma urealyticumassociationbronchopulmonary dysplasiameta-analysispreterm infants

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