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Bioprinted research models of urological malignancy
Guanyi Wang1,2, Xiongmin Mao1, Wang Wang1
1Department of Urology Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center Zhongnan Hospital of Wuhan University Wuhan China.
Exploration (Beijing, China)
|August 23, 2024
Summary
Bioprinted research models (BRMs) offer advanced capabilities for studying urological malignancy (UM), overcoming limitations of traditional methods. These models enable better understanding and treatment development for UM.
Area of Science:
- Biomedical Engineering
- Oncology
- Regenerative Medicine
Background:
- Urological malignancy (UM) presents a significant global health challenge.
- Despite extensive research, current UM investigation methods yield unsatisfactory results.
- Bioprinted research models (BRMs) offer a promising alternative for advancing UM research.
Purpose of the Study:
- To provide a comprehensive review of bioprinted research models (BRMs) for urological malignancy (UM).
- To highlight the advantages of BRMs over traditional UM research models.
- To discuss current challenges and future directions in the field.
Main Methods:
- Review of existing UM research models and their limitations.
- Summary of six mainstream bioprinting techniques for BRM fabrication.
- Discussion of BRM applications in UM research.
Main Results:
- BRMs can accurately model real tissues and organs, offering superior research capabilities.
- Applications include culturing tumor spheroids/organoids, modeling metastasis, and mimicking the tumor microenvironment.
- BRMs are utilized in constructing organ chips for drug screening and isolating circulating tumor cells.
Conclusions:
- BRMs represent a disruptive technology with significant potential to advance urological malignancy research.
- Interdisciplinary approaches are crucial for addressing current challenges and future development.
- BRMs are poised to revolutionize the study and treatment of UM.
