Bioimaging and prospects of night pearls-based persistence phosphors in cancer diagnostics

Inorganic persistent phosphors feature great potential for cancer diagnosis due to the long luminescence lifetime, low background scattering, and minimal autofluorescence. With the prominent advantages of near-infrared light, such as deep penetration, high resolution, low autofluorescence, and tissue absorption, persistent phosphors can be used for deep bioimaging. We focus on highlighting inorganic persistent phosphors, emphasizing the synthesis methods and applications in cancer diagnostics. Typical synthetic methods such as the high-temperature solid state, thermal decomposition, hydrothermal/solvothermal, and template methods are proposed to obtain small-size phosphors for biological organisms. The luminescence mechanisms of inorganic persistent phosphors with different excitation are discussed and effective matrixes including galliumate, germanium, aluminate, and fluoride are explored. Finally, the current directions where inorganic persistent phosphors can continue to be optimized and how to further overcome the challenges in cancer diagnosis are summarized.