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A Rare Lung Malignancy in a Case of Systemic Sclerosis
Syed Akram C1, Harshavardhini P1, Nalini Jayanthi1
1Department of Respiratory Medicine, SRM Medical College Hospital and Research Centre, Chennai, IND.
Cureus
|August 23, 2024
Summary
Systemic sclerosis (SSc) patients have a higher risk of lung cancer. This case highlights adenosquamous carcinoma in a long-term SSc patient, emphasizing the need for lung cancer screening in this population.
Area of Science:
- Rheumatology
- Pulmonology
- Oncology
Background:
- Systemic sclerosis (SSc) is a chronic autoimmune disease marked by collagen deposition.
- SSc is linked to an increased incidence of internal malignancies, particularly lung cancer.
Observation:
- A 55-year-old non-smoking female with a decade-long history of diffuse cutaneous SSc presented with worsening cough and dyspnea.
- Imaging revealed a new lung lesion, and a biopsy confirmed adenosquamous carcinoma.
Findings:
- The patient had established SSc with interstitial lung disease (ILD) and presented with a newly diagnosed primary pulmonary adenosquamous carcinoma.
- This case represents a rare occurrence of lung malignancy in a patient with long-standing SSc and ILD.
Implications:
- This case underscores the heightened risk of lung cancer in SSc patients, especially those with ILD.
- Routine lung cancer screening is crucial for individuals with SSc and ILD to ensure early detection and management.
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