Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Arteries of the Lower Limbs01:24

Arteries of the Lower Limbs

181
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
181
Seizures: Classification01:13

Seizures: Classification

309
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
309
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

29
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
29

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond Ketosis: Dietary Therapies and the Microbiota-Gut-Brain Axis in Epilepsy.

Nutrients·2026
Same author

Neuropsychological functioning and progression in Lafora disease.

Epilepsia·2026
Same author

Expanding clinical variability in FBXW7-related neurodevelopmental disorder: a multicenter case series.

Journal of neurodevelopmental disorders·2026
Same author

Exploring the Role of Early Add-On Cenobamate in Uncontrolled Focal Epilepsy: A Critical Appraisal of the Evidence.

Neurology and therapy·2026
Same author

Diagnostic yield and copy number variants findings in 219 adult patients with developmental and epileptic encephalopathy.

Epilepsia·2026
Same authorSame journal

Expanding the electroclinical spectrum of TANC2-related disorders: Lennox-Gastaut syndrome and related developmental epileptic phenotypes.

Epilepsia open·2026

Related Experiment Video

Updated: Jun 15, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

2.6K

Italian report on RARE epilepsies (i-RARE): A consensus on multidisciplinarity.

Antonella Riva1, Antonietta Coppola2, Francesca Bisulli3,4

  • 1Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.

Epilepsia Open
|August 23, 2024
PubMed
Summary

Consensus was reached on managing rare epilepsies and developmental and epileptic encephalopathies (DEEs). Key recommendations include personalized, multidisciplinary care and further research into epidemiology and treatments to improve patient outcomes.

Keywords:
DEEsDelphimanagementmultidisciplinarityrare epilepsies

More Related Videos

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

8.9K
Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

20.7K

Related Experiment Videos

Last Updated: Jun 15, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

2.6K
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

8.9K
Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

20.7K

Area of Science:

  • Neurology
  • Epileptology
  • Public Health

Background:

  • Rare epilepsies are diverse neurological disorders with significant impact.
  • Effective management requires a unified approach among specialists and patient advocates.

Purpose of the Study:

  • To establish a national consensus on key issues in rare and complex epilepsies.
  • To guide clinical practice and healthcare policy for these conditions.

Main Methods:

  • A modified Delphi method was employed with a scientific board of physicians and patient advocates.
  • A 32-member expert panel from Italy validated consensus statements via a two-round voting process.

Main Results:

  • Sixteen statements achieved consensus, highlighting the need for epidemiological studies on rare epilepsies.
  • Etiology is critical for treatment and prognosis; early interventions are vital for developmental and epileptic encephalopathies (DEEs).
  • Multidisciplinary care and focus on non-seizure outcomes in adolescence/adulthood are essential.

Conclusions:

  • A personalized, comprehensive, and multidisciplinary approach is imperative for managing rare epilepsies/DEEs.
  • Increased research in epidemiology and therapeutics is crucial for evidence-based decision-making and policy.
  • The consensus provides a framework for enhancing patient outcomes through integrated care.