Dose-related response of mouse mamma to some phenothiazine drugs

The dose-related response of the mammary growth was studied in immature ICR-JCL female mice given 0.03 micrograms of estradiol per animal subcutaneously, and 0.005-1.0mg of either of the following phenothiazines (chlorpromazine, levometh iomeprazine, promethazine, perphenazine, thioridazine and propericiazine) per 10g of body weight was given orally once a day for 9 days starting on the 5th day after ovariectomy. The right second mamma of the chest was used to compare the hypertrophic affects. All the phenothiazines used produced mammary growth in the intensity sequence of thioridazine greater than chlorpromazine greater than promethazine greater than propericiazine greater than perphenazine greater than levomethiomeprazine. An optimal dose of each of the phenothiazines required to produce the maximum hypetrophy of the mammary gland was examined. From the results obtained, the relationship between the side-chain moiety of the compounds and the mammary growth activity could not be revealed.