Related Experiment Video

Updated: May 5, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.9K

Idiopathic Systemic Capillary Leak Syndrome: Report of a Pediatric Case

João Vasco1, Francisca Albuquerque2, Francisca Costa3

  • 1Serviço de Pediatria. Hospital do Divino Espírito Santo. Ponta Delgada. Portugal.

Acta Medica Portuguesa
|August 23, 2024
PubMed

Insights

Idiopathic systemic capillary leak syndrome (ISCLS) causes sudden fluid loss, leading to shock. This case highlights ISCLS phases in a child, emphasizing diagnostic challenges.

Area of Science:

  • Pediatrics
  • Internal Medicine
  • Critical Care Medicine

Background:

  • Idiopathic systemic capillary leak syndrome (ISCLS) is a rare disorder.
  • ISCLS is characterized by recurrent episodes of hypovolemia and shock.
  • The exact cause of ISCLS remains unknown.

Observation:

  • A previously healthy seven-year-old boy presented with prodromal symptoms including abdominal pain, fatigue, and nausea.
  • The patient experienced a fluid extravasation phase with hemoconcentration, hypoproteinemia, and muscular edema.
  • Compartment syndrome developed in the abdominal wall and lower limbs due to edema.

Findings:

  • The patient exhibited the three distinct phases of ISCLS: prodromal, extravasation, and recovery.
  • Inflammatory markers and blood cultures remained negative throughout the illness.
  • Spontaneous and rapid clinical and analytical recovery was observed within days.

Implications:

  • This case illustrates the typical presentation and course of ISCLS in a pediatric patient.
  • Early recognition and diagnosis of ISCLS are crucial due to its potential fatality.
  • Differentiating ISCLS from other causes of shock is a significant clinical challenge.

Keywords:
Capillary Leak SyndromeChildShock

More Related Videos

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

6.6K
Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation06:59

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation

Published on: February 29, 2020

8.1K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
975
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
558
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.2K
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
422
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
31
Pulmonary Edema II: Pathophysiology01:18

Pulmonary Edema II: Pathophysiology

Pulmonary edema is the accumulation of fluid in the interstitial and alveolar spaces of the lungs, impairing gas exchange and oxygen delivery. It may be cardiogenic or noncardiogenic, but both reduce oxygenation and lung compliance.Cardiogenic Pulmonary EdemaCardiogenic edema results from increased hydrostatic pressure in pulmonary capillaries, usually due to left ventricular dysfunction from myocardial infarction, heart failure, or valvular disease. Ineffective cardiac pumping causes blood to...
76