XPO1 serves as a prognostic marker involving AKT/MAPK/TGFBR1 pathway in OSCC
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View abstract on PubMed
Summary
This summary is machine-generated.Exportin 1 (XPO1) is elevated in oral squamous cell carcinoma (OSCC), indicating a poor prognosis. XPO1 promotes OSCC development via AKT/MAPK/TGFBR1 signaling and impacts immune infiltration.
Area Of Science
- Oncology
- Molecular Biology
- Cancer Research
Background
- Exportin 1 (XPO1) is a nuclear export protein implicated in tumor development and serves as a therapeutic target.
- Its specific role in oral squamous cell carcinoma (OSCC) remained undetermined prior to this study.
Purpose Of The Study
- To investigate the role and prognostic significance of Exportin 1 (XPO1) in oral squamous cell carcinoma (OSCC).
- To explore the molecular pathways and immune interactions associated with XPO1 in OSCC.
Main Methods
- Bioinformatic analysis of XPO1 mRNA expression in OSCC.
- Immunohistochemical validation of XPO1 protein levels in OSCC specimens.
- Survival analysis, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and immune infiltration analysis.
Main Results
- XPO1 mRNA and protein expression are significantly upregulated in OSCC, correlating with disease severity.
- Elevated XPO1 expression is associated with poorer patient survival.
- XPO1 mediates cell cycle and DNA replication pathways, reduces immune infiltration, and positively correlates with AKT/MAPK/TGFBR1 signaling.
Conclusions
- XPO1 serves as a marker of poor prognosis in OSCC.
- XPO1 promotes OSCC progression, potentially through the AKT/MAPK/TGFBR1 signaling pathway.
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