Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Why do patients with lupus nephritis die?

P Correia, J S Cameron, J D Lian

    British Medical Journal (Clinical Research Ed.)
    |January 12, 1985
    PubMed
    Summary

    Systemic lupus erythematosus (SLE) significantly impacts survival, with many patients experiencing death or renal failure. Active lupus and infection are primary causes of mortality, especially after dialysis initiation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Confidentiality and the duties of care.

    Journal of medical ethics·2003
    Same author

    Informed consent for cancer registration.

    The Lancet. Oncology·2002
    Same author

    Rights involve responsibilities for patients. Doctors must not generally pass personal information about patients to others without consent.

    BMJ (Clinical research ed.)·2001
    Same author

    Medical versus surgical treatment in children with severe bilateral vesicoureteric reflux and bilateral nephropathy: a randomised trial.

    Lancet (London, England)·2001
    Same author

    The role and education of doctors in the delivery of health care.

    Lancet (London, England)·1999
    Same author

    Parathyroid carcinoma secondary to prolonged hyperplasia in chronic renal failure and in coeliac disease.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·1999

    Area of Science:

    • Nephrology
    • Rheumatology
    • Immunology

    Background:

    • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with significant morbidity and mortality.
    • Renal involvement is a common and serious complication of SLE, often leading to end-stage renal disease.

    Purpose of the Study:

    • To analyze mortality and causes of death in patients with systemic lupus erythematosus over a 20-year period.
    • To investigate the factors influencing survival, including renal failure, active disease, infection, and vascular complications.

    Main Methods:

    • Retrospective analysis of 138 patients with SLE over 20 years.
    • Data collection on mortality, renal failure, dialysis treatment, and causes of death.
    • Correlation of outcomes with disease activity, rate of renal function decline, and presence of comorbidities.

    Related Experiment Videos

    Main Results:

    • 42 of 138 patients died or reached terminal renal failure; data from 41 analyzed.
    • Active lupus and infection were principal causes of death, particularly after dialysis initiation.
    • Vascular disease was a significant cause of death in younger patients; severe coronary artery atheroma noted in 8/15 postmortems.

    Conclusions:

    • Uncontrolled lupus remains the primary cause of death in SLE patients, despite aggressive treatment.
    • Rapid deterioration of renal function is associated with higher mortality.
    • Vascular complications represent a significant, often underappreciated, cause of mortality in SLE.