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Updated: Jun 15, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Trajectories of cardiovascular ageing-from molecular mechanisms to clinical implementation

Stefano Ministrini1, Florian A Wenzl1,2,3,4, Thomas F Lüscher1,5

  • 1Center for Molecular Cardiology, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland.

Cardiovascular Research
|August 23, 2024
PubMed

Insights

Aging impacts the cardiovascular system through molecular mechanisms like telomere shortening. Understanding these aging hallmarks allows for measuring biological age and developing interventions to counteract cardiovascular aging.

Area of Science:

  • Cardiovascular Science
  • Aging Biology
  • Molecular Medicine

Background:

  • The cardiovascular system's unique structure makes it susceptible to age-related decline.
  • Molecular mechanisms driving aging, such as telomere shortening and antioxidant production, are increasingly understood.
  • Biological aging is characterized by multiple hallmarks, including genomic instability, inflammation, and dysbiosis.

Purpose of the Study:

  • To review the role of aging hallmarks in cardiovascular health.
  • To summarize methods for measuring biological age at cellular and molecular levels.
  • To explore potential pharmacological and non-pharmacological interventions against cardiovascular aging.

Main Methods:

  • Narrative review of current scientific literature.
  • Focus on molecular mechanisms and hallmarks of aging.
  • Analysis of measurement techniques and intervention strategies.

Main Results:

  • Aging hallmarks significantly impact cardiovascular structure and function.
  • Various methods exist to quantify biological age, reflecting molecular and cellular changes.
  • Interventions targeting aging hallmarks show promise in mitigating cardiovascular aging.

Conclusions:

  • Cardiovascular aging is a complex process driven by multiple molecular hallmarks.
  • Measuring biological age offers insights into individual aging trajectories.
  • Targeting aging hallmarks presents therapeutic opportunities for cardiovascular health.

Keywords:
Ageing hallmarksAutophagyCardiovascular ageingEpigenetic clocksInflamm-ageingSirtuins

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