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  1. Home
  3. Investigating The Impact Of The Inflammatory Immune Microenvironment And Steroids Or Cox-2 Inhibitors Usage On Immunotherapy In Advanced Esophageal Squamous Cell Carcinoma (escc): A Propensity Score Matched Analysis.
  1. Home
  3. Investigating The Impact Of The Inflammatory Immune Microenvironment And Steroids Or Cox-2 Inhibitors Usage On Immunotherapy In Advanced Esophageal Squamous Cell Carcinoma (escc): A Propensity Score Matched Analysis.

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Investigating the impact of the inflammatory immune microenvironment and steroids or COX-2 inhibitors usage on

Huihui Li1,2, Ning Chen3,4, Wenjing Wang3,2

  • 1Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Yangpu District, Shanghai, 200433, China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|August 23, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
BiomarkersEsophagus cancerImmune microenvironmentImmunotherapy

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Lower pre-treatment Neutrophil/Lymphocyte Ratio (NLR) and C-reactive protein to albumin ratio (CRP/ALB) predict better outcomes for advanced esophageal cancer patients on immunotherapy. Steroid or COX-2 inhibitor use did not significantly impact survival.

Area of Science:

  • Oncology
  • Immunotherapy
  • Biomarker Research

Background:

  • Advanced esophageal squamous cell carcinoma (ESCC) presents significant treatment challenges.
  • Immune checkpoint inhibitors (ICIs) have emerged as a promising therapeutic strategy for advanced ESCC.
  • Predictive biomarkers are crucial for optimizing ICI therapy efficacy and patient selection.

Purpose of the Study:

  • To investigate the association between pre-treatment inflammatory biomarkers and clinical outcomes in advanced ESCC patients receiving ICIs.
  • To evaluate the impact of Neutrophil/Lymphocyte Ratio (NLR), C-reactive protein to albumin ratio (CRP/ALB), Glasgow Prognostic Score (GPS), and the use of steroids or COX-2 inhibitors on immunotherapy effectiveness and survival.

Main Methods:

  • Retrospective analysis of 354 patients with metastatic ESCC treated with immunotherapy between 2019 and 2022.
  • Assessment of pre-treatment NLR, CRP/ALB, GPS, and concomitant use of steroids or COX-2 inhibitors.
  • Statistical analysis using Kaplan-Meier curves, Cox regression models, and propensity score matching.

    • Main Results:

    • Elevated pre-treatment NLR and CRP/ALB levels were significantly correlated with poorer overall survival (OS).
    • No significant difference in OS was observed based on the use of steroids (p=0.685) or COX-2 inhibitors (p=0.054).

    Conclusions:

    • Lower pre-treatment NLR and CRP/ALB are associated with improved effectiveness and OS in advanced ESCC patients undergoing immunotherapy.
    • Steroid or COX-2 inhibitor use did not demonstrate a significant impact on overall survival in this patient cohort.