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Potential bladder cancer therapeutic delivery systems: a recent update

Oluwadamilola M Kolawole1, Vitaliy V Khutoryanskiy2

  • 1Department of Pharmaceutics and Pharmaceutical Technology, University of Lagos, Lagos, Nigeria.

Expert Opinion on Drug Delivery
|August 23, 2024
PubMed
Abstract

Insights

Developing advanced drug delivery systems, like functionalized nanoparticles in gelling systems, offers improved bladder cancer treatment with controlled release and tumor targeting. Future research may involve combination therapies and smart nanomaterials for better patient outcomes.

Area of Science:

  • Oncology
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Bladder cancer treatment is costly due to therapy and surveillance needs.
  • There's a critical demand for effective, targeted drug formulations to improve patient prognosis.
  • Current treatments face challenges in drug release control and tumor specificity.

Purpose of the Study:

  • To review drug formulations for bladder cancer treatment over the past decade.
  • To highlight recent advancements, clinical trials, and FDA-approved drugs.
  • To identify barriers hindering the clinical translation of promising drug delivery systems.

Main Methods:

  • Review of scientific literature on bladder cancer drug formulations.
  • Analysis of recent trends in bladder cancer treatment strategies.
  • Examination of clinical trial data and regulatory approvals.

Main Results:

  • Surface-functionalized nanoparticles in in situ gelling systems enhance controlled drug release.
  • These advanced systems show potential for improved bladder cancer treatment prognosis.
  • Challenges remain in translating laboratory research into clinical applications.

Conclusions:

  • Particulate drug delivery systems with surface functionalization and in situ gelling show promise for bladder cancer.
  • Future directions include multi-drug systems and smart nanomaterials like photothermal therapies.
  • Overcoming translational barriers is key to improving therapeutic outcomes for bladder cancer patients.
Keywords:
Bladder cancerFDA approvalclinical trialsin vitro and in vivo evaluationpreclinicaltherapeutic delivery system

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