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TBHP Promotes Cross-Dehydrogenative Coupling of SF4 Alkynes with Tetrahydroisoquinolines under Copper Catalysis
Srikanth Reddy Narra1, Putri Nur Arina Mohd Ariff1, Debarshi Saha1
1Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Gokiso, Showa-ku Nagoya 466-8555, Japan.
Abstract:
We present a viable approach for the cross-dehydrogenative coupling of Het-SF4-alkynes with tetrahydroisoquinolines under oxidative conditions, using TBHP and copper catalysts. These newly developed conditions boast enhanced yields and a more extensive range of substrates, demonstrating tolerance to various functional groups and addressing the limitations of earlier reports. Consequently, this method should increase opportunities for the exploration of SF4-containing compounds and their potential applications in drug discovery, materials science, and as alternatives to PFAS.
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