Hybrid-feature based spherical quasi-conformal registration for AD-induced hippocampal surface morphological changes
Xiangying Wang1, Wenqiang Cui2, Hongyun Wu2
1First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Computer Methods and Programs in Biomedicine
|August 23, 2024
Summary
This study introduces a novel hybrid-feature based spherical quasi-conformal registration (HSQR) method for accurately mapping hippocampal surfaces. HSQR effectively identifies Alzheimer's disease (AD) and mild cognitive impairment (MCI) related hippocampal changes, aiding in diagnosis and tracking.
Area of Science:
- Neuroimaging
- Medical Image Analysis
- Computational Anatomy
Background:
- Accurate registration of hippocampal surfaces is crucial for analyzing Alzheimer's disease (AD)-induced changes.
- Existing methods struggle with large inter-subject variations, leading to inaccurate feature matching and loss of bijective mapping.
- This necessitates a robust registration technique that preserves anatomical integrity and accurately captures morphological details.
Purpose of the Study:
- To develop and validate a hybrid-feature based spherical quasi-conformal registration (HSQR) method.
- To ensure accurate one-to-one morphological correspondence between hippocampal surfaces.
- To effectively maintain diffeomorphic properties while adhering to hybrid-feature matching constraints.
Main Methods:
- Hybrid feature extraction: Combined anatomical landmarks and mean curvature for comprehensive surface description.
- Spherical parameterization: Applied to genus-0 closed surfaces (hippocampus) to preserve local morphology via area-preserving properties.
- Novel spherical quasi-conformal registration: Handled large deformations by projecting to a 2D plane, controlled by the Beltrami coefficient for bijective alignment.
Main Results:
- The HSQR method was validated on a cohort from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (161 AD, 234 MCI, 266 cognitively unimpaired individuals).
- HSQR demonstrated stronger statistical power in detecting morphological differences between cognitively unimpaired (CU) vs. mild cognitive impairment (MCI) groups (q-values: 0.0453 left, 0.0401 right hippocampus).
- Significant differences were also found between Alzheimer's disease (AD) vs. MCI groups (q-values: 0.0282 left, 0.0421 right hippocampus).
Conclusions:
- The developed HSQR algorithm provides a robust foundation for precise quantification of hippocampal surface morphology.
- This method supports accurate differential diagnosis and tracking of Alzheimer's disease progression.
- HSQR facilitates a deeper understanding of AD-related neurodegenerative changes in the hippocampus.
Related Concept Videos
02:11Conformations of Cyclohexane
12.2K
Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
12.2K
02:18Fischer Projections
12.9K
Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines.
12.9K
00:55Composite Bodies
1.6K
A composite body is a body made up of multiple parts, connected to form a larger, unified object. Each part has its own weight and center of gravity, which must be considered to determine the center of gravity of the composite body. In cases where the density or specific weight is constant, the center of gravity coincides with the centroid.
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
1.6K
01:25Shape and Texture of Coarse Aggregate
1.3K
Aggregate shape is classified based on the relative sharpness or roundness of the edges and corners. This classification includes categories like rounded, angular, elongated, and flaky, each with specific characteristics. Rounded aggregates, fully shaped by attrition, are typical of river or seashore gravel, while angular aggregates, such as crushed rock, have well-defined edges. Aggregates that are elongated and flaky are less desirable, as they can reduce the workability and strength of...
1.3K
01:11Buoyancy and Stability for Submerged and Floating Bodies
3.6K
In fluid mechanics, buoyancy and stability are key concepts for understanding the behavior of submerged and floating bodies. When a stationary body is fully or partially submerged in a fluid, the fluid exerts a force on the body known as the buoyant force. This force acts vertically upward through a point called the center of buoyancy, which is the center of the displaced fluid volume. According to Archimedes' principle, the magnitude of the buoyant force is equal to the weight of the fluid...
3.6K
01:28Simpson's Rule II
242
In warehouse roofing applications, corrugated or curved metal sheets are commonly used to improve structural strength, water drainage, and ventilation efficiency. To accurately estimate material requirements and optimize design parameters, engineers must determine the curved surface area of these sheets. Because the sheet profiles often repeat smoothly along their length, they can be effectively approximated by parabolic curves, enabling the use of numerical integration techniques for area...
242