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NMR Spectrometers: Overview

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NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...

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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

A complete 3D-printed tool kit for Solid-State NMR sample and rotor handling.

Martin A Olson¹, Ruixian Han², Thirupathi Ravula³

¹Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706 USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)

|August 23, 2024

Summary

This summary is machine-generated.

This study introduces 3D-printed tools to streamline solid-state NMR (SSNMR) sample preparation. These tools enhance the reliability of rotor packing, marking, and storage, reducing disruptions in biomolecular and materials research.

Keywords:

3D Printing Rotor packing Sample preparation Tachometer marking

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Area of Science:

Materials Science
Analytical Chemistry
Biophysics

Background:

Solid-state NMR (SSNMR) is crucial for analyzing biomolecules and materials.
Sample preparation for SSNMR, including rotor handling, can be challenging and time-consuming.
Difficulties in sample preparation, especially with smaller rotors, hinder widespread adoption and cause instrument downtime.

Purpose of the Study:

To develop and present a set of novel tools for improving SSNMR sample preparation workflows.
To address common issues encountered during rotor packing, unpacking, tachometer marking, and storage.
To enhance the reliability and robustness of SSNMR experiments, particularly in large-facility settings.

Main Methods:

Utilized stereolithography 3D printing for cost-effective prototyping and manufacturing.
Designed a range of tools tailored for various probe and rotor geometries.
Focused on improving routine tasks such as sample transfer, rotor insertion, and tachometer signal detection.

Main Results:

Developed a comprehensive suite of tools for efficient and reproducible SSNMR sample preparation.
Demonstrated the effectiveness of 3D printing in creating precise and functional laboratory equipment.
Successfully addressed common operational challenges, reducing delays and improving instrument uptime.

Conclusions:

The developed 3D-printed tools significantly improve the reliability and ease of SSNMR sample preparation.
These tools offer a practical solution for both novice and experienced SSNMR users.
The adoption of these tools can lead to more efficient utilization of valuable scientific instrumentation.