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Mucosal immune responses in peri-parturient dairy cattle
Victor S Cortese1, Amelia Woolums2, Merrilee Thoresen2
1Cortese Veterinary Consulting LLC, 10910 Rock Valley Court, Louisville, KY 40241, USA.
Veterinary Microbiology
|August 23, 2024
Summary
Peripartum Holstein cows maintained intact mucosal immune responses, unaffected by intranasal modified live viral vaccination or genotype. Immune responses, including interferon beta and IgA, showed significant time-dependent changes post-calving.
Area of Science:
- Veterinary Immunology
- Bovine Health
- Mucosal Immunity
Background:
- Peripartum period is critical for bovine health.
- Systemic immunosuppression is often reported during this phase.
- Mucosal immunity's role in peripartum cattle requires further investigation.
Purpose of the Study:
- Evaluate mucosal immune responses in peripartum Holstein cows.
- Assess the impact of intranasal modified live viral (MLV) vaccination on mucosal immunity.
- Explore genotype-specific relationships with peripartum immune responses.
Main Methods:
- Randomized controlled trial with 80 Holstein cows.
- Intranasal MLV vaccination at pre-calving, post-calving, or both time points.
- Measurement of nasal and serum immune markers (IFN-beta, IFN-gamma, IgA, SN titers) and genotyping.
Main Results:
- No significant effect of vaccination timing on overall immune responses.
- Numerically increased IFN-gamma observed post-vaccination in all vaccinated groups.
- Significant time-dependent increases in nasal IgA and IFN-beta post-calving.
- No significant genotype-immune response relationships detected.
Conclusions:
- Bovine mucosal immune responses remain intact during the peripartum period.
- Intranasal MLV vaccination did not significantly alter peripartum mucosal immunity.
- Genotype did not appear to influence peripartum immune responses in this study.
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