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Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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A nutrigeroscience approach: Dietary macronutrients and cellular senescence
Mariah F Calubag1, Paul D Robbins2, Dudley W Lamming1
1Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA; Graduate Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Cell Metabolism
|August 23, 2024
Summary
Dietary macronutrients can impact cellular senescence, a key aging process. Understanding these effects may help develop nutritional strategies for healthier aging and metabolic health.
Area of Science:
- Gerontology
- Cell Biology
- Nutritional Science
Background:
- Cellular senescence, a state of irreversible cell cycle arrest, is a hallmark of aging.
- Senescence-associated secretory phenotype (SASP) contributes to tissue dysfunction and metabolic disorders.
- Dietary interventions are explored for combating age-related metabolic decline.
Purpose of the Study:
- To review the impact of dietary macronutrients on cellular senescence and SASP.
- To explore nutrient-responsive molecular mechanisms.
- To inform a nutrigeroscience approach for healthy aging.
Main Methods:
- Literature review of studies on diet, senescence, and SASP.
- Analysis of molecular pathways linking nutrient sensing to senescence.
- Synthesis of findings for potential therapeutic applications.
Main Results:
- Dietary interventions, including caloric restriction and specific macronutrients, influence senescence.
- Metabolic benefits of dietary interventions may be mediated by reduced senescence.
- Specific nutrient-sensing pathways are implicated in diet-induced modulation of senescence.
Conclusions:
- Dietary macronutrients play a significant role in regulating cellular senescence and SASP.
- Targeting nutrient-responsive pathways offers a potential strategy for mitigating age-related dysfunction.
- Nutrigeroscience holds promise for promoting healthy aging through dietary modulation of senescence.
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