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Flexible control of sequence working memory in the macaque frontal cortex.

Jingwen Chen1, Cong Zhang1, Peiyao Hu1

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The brain flexibly controls sequence working memory (SWM) by organizing neural activity in the frontal cortex. This allows items to be bound to their correct order for recall.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • Memorizing sequences requires binding items to their rank order.
  • The neural mechanisms controlling sequence working memory (SWM) are not well understood.

Purpose of the Study:

  • To investigate the neural representations and control mechanisms underlying SWM.
  • To explore how the brain binds item and rank information in SWM.

Main Methods:

  • Electrophysiological recordings in macaque monkey frontal cortex.
  • Performing forward and backward sequence working memory tasks.
  • Analysis of neural population dynamics within low-dimensional subspaces.

Main Results:

  • Identified separate, generalizable subspaces for sensory and memory information in the frontal cortex.
  • Observed organized dynamics within these subspaces reflecting SWM control.
  • Demonstrated flexible routing of sensory information into rank-selective SWM subspaces based on task demands.
  • Neural activity in SWM subspaces predicted recalled item and order, even in error trials.

Conclusions:

  • Compositional neural population codes with orchestrated dynamics in the frontal cortex support flexible SWM control.
  • The findings reveal a neural framework for how the brain manages ordered information in working memory.